A Small Animal PET∕SPECT∕CT Imaging System
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Tumor Imaging - Time-course of healthy lung volume degradation during breast tumor metastasis. Calli Davison of the Schafer Lab is studying breast cancer metastasis in living mice using non-invasive X-ray computed tomography on the Albira PET/SPECT/CT. Two cohorts of mice were injected with either breast cancer cells, or saline (control), and were imaged over a period of six weeks. The lung tissue volume was segmented (shown above in purple) and quantified for each group. The lung destruction caused by tumor growth is readily apparent from the in vivo images. The Schafer lab is currently using this technology to study the metastatic properties of breast cancer cell lines with altered expression levels of the enzyme catalase.
Imaging Brain Stroke – Professor Rashna Balsara is using Emission Tomography (PET) to image brain metabolism in rats with cerebral ischemia. The image shows CT (anatomical map, left), PET (CENTER AND pet-CT overlay (right) of a rat 24 hours after a stroke event.
Evan Doney of the Leevy Lab is developing novel methods that combine peclinical imaging and additive manufacturing. Rats scanned with the Albira Image Station X-ray CT modality (top) were rendered and edited as stereolithographs and printed as physical models bottom using a number of 3D printing platforms, including Shapeways.com (bottom) Soft tissue segmentation, printing in multiple colors and model customization are also possible with this newly developed method. The Integrated Imaging Facility currently has two 3D printers and is improving and expanding these methods to the microscopic level to include human data, as well as cells and organelles