The left side shows the cells in a live zebrafish through a conventional microscope, contrasted with a higher-resolution DeSOS version on the right.
During his postdoctoral research, Notre Dame electrical engineer Scott Howard wanted to produce more precise images of the activity within a cell by increasing the power of the microscope’s laser.
When he experimented with different power levels, he discovered that his computer was receiving an extra copy of image data.
“When you push the lasers up too high, it would scramble the data because the different parts inside the cell get saturated and can’t absorb any more light,” Howard said. “But I was getting this extra copy that I called a ‘ghost image.’”
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Originally published by Brendan O'Shaughnessy at nd.edu on September 30, 2019.