Bruker Xtreme

Bruker Xtreme

An Optical and X-ray Small Animal Imaging System

For more information on using this instrument, view our policies and rates.

Optical Imaging of RFP Ovarian Cancer Mets

Optical Imaging of RFP Ovarian Cancer Mets – The Cowden-Dahl lab is using RFP-expressing ovarian cancer cells to track and quantify tumor metastasis during ex vivo imaging.  The image at right shows a photo of an IP region of a mouse (left), the RFP fluorescence image (center), and an overlay of both.


Multimodal Extreme

Multimodal Prostate Tumor Imaging –A collaboration between researchers from the Suckow Lab , Leevy Lab, and Dr. Brian Rabinovich from MD Andersen, has produced aprostate tumor cell line with dual bioluminescent and fluorescent genetic reporters . From left to right is a sub-Q tumor with signal captured in photographic,mCherry fluorescence, exogenous MMPSense750 probe fluorescence, Cerenkov luminescence (FDG), and PET (FDG) modalities.

P. Aeruginosa

Dynamic Imaging of P. aeruginosa Swarm Behavior- Researchers from the lab of Prof. Joshua Shrout are performing time-lapse fluorescence imaging GFP-expressing bacteria to monitor their growth and swarm kinetics.  At left is a single frame from a three-day time course, in which a “fire” color scale is used to indicated the intensity of GFP signal coming from different regions on the plate.

Fluorescence Imaging of Bone Remodeling

Fluorescence Imaging of Bone Remodeling – The MSFX specializes in the detection of fluorescent probes in living mice. At right is a montage of X-ray, fluorescence, and overlay of a mouse injected with Osteosense-750, a probe for bone remodeling. Image generated by undergraduate researchers in the Leevy Lab.