GE Healthcare DeltaVision Deconvolution Microscope

The DeltaVision’s greatest strength is its ability to obtain long-term time-lapse three-dimensional images with a minimum of photodamage on live cells.  Then with it’s deconvolution algorithm redirects all out of focus light to become in focus for sharp images. For more information on using this instrument, view our policies and rates.

Ge Healthcare Deltavision Data1

Chromosomal Architecture - Through the genome of Culex, a mosquito vector for West Nile Virus and Japanese encephalitis, is sequenced. The genome's highly repetitive sequences have prevented genomic sequences from being correctly oriented and connected to each other. Maria Unger of the Collins Lab is using the DeltaVision to visualize fluourescently marked chromosomes in Culex Malpighian tubule cells in order to correctly connect and align these sequences.

Ge Healthcare Deltavision Data2

Imaging of Subcellular Structures - Using three separate fluorescence channels, James Kasuboski of the Vaughan Lab uses DeltaVision to examine the structure, assembly, and behavior of kinetochores in live cultures COS-7 cells. Insights gleaned from such work contributes to our understanding of cellular mechanics underlying many conditions, including cancer. The images below show cells during metaphase period of cell division.