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Giles E. Duffield

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2013 Best Biological Publication Imaging Award

The 2013 Best Biological Imaging Publication was awarded to Giles E. Duffield, associate professor of biological sciences. Duffield and his coworkers have pioneered the use of Positron Emission Tomography (PET) to monitor the daily rhythms of small living animals. The researchers use 18-F-fluorodeoxyglucose (FDG), a radiolabeled sugar that is a PET marker for tissue metabolism levels. The authors investigated the effect of ID2 gene ablation on FDG biodistribution in mice. The PET imaging results showed altered circadian feeding behavior, sex-specific enhancement of insulin sensitivity, and elevated glucose uptake in skeletal muscle and brown adipose tissue. The findings indicate a role for ID2 as a regulator of glucose and lipid metabolism, and contribute to the understanding of the development of obesity and diabetes, particularly in shift work personnel. The study was published in PLoS One.