The Notre Dame Integrated Imaging Facility (NDIIF) is a state-of-the-art research core facility that consolidates the University's imaging capacity and augments it with powerful new imaging modalities.

NDIIF provides an integrated suite of sophisticated microscopes and imaging stations that enable expert users to address the most complex modern research problems. Expert staff, including technicians and research specialists, are available to guide non-expert users.

The facility is divided into four areas of imaging expertise:

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    Electron Microscopy Core

    The Electron Microscopy Core integrates a unique bundle of state-of-the-art FEI tools that enable users to attack the most complex modern research problems from micron to Angstrom spatial resolution.

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    Optical Microscopy Core

    The Optical Microscopy Core provides researchers with the opportunity to acquire informative single images and three-dimensional reconstructions of fluorescently labeled cells and tissues, either fixed or live.

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    In Vivo Imaging Core

    The Vivo Imaging Core provides a non-invasive approach to observe various disease and biological conditions in living systems.

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    Histology Core

    The Histology Core provides a means to examine biological processes in mice, rats, frogs, zebra fish, fruit flies, sheep bone, and even human tissue by use of immunohistochemical techniques and pathology.

The NDIIF supports an interactive network of research groups, who are connected by their interest in imaging technology, which enables them to cross-fertilize ideas and form interdisciplinary collaborations. The facility is open to the Notre Dame research community, external academic institutions, and industry. Additionally, it is an approved Indiana Clinical and Translational Sciences Institute (CTSI) core facility, with services available to all CTSI partners.


The overall mission of the Notre Dame Integrated Imaging Facility is to provide state-of-the-art technology to tackle non-invasively image disease models and biological processes in living systems.

Discovering new trends in in-situ and high-resolution imaging and microscopy for nanotechnology, materials, and bio-sciences.