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Yuliya Klymenko

Klymenko Neoplasiaslide

2017 Best Electron Microscopy Publication Imaging Award

The 2017 Best Electron Beam Imaging Publication was awarded to Yuliya Klymenko in the group of Professor Sharon Stack, Director of Harper Cancer Research Institute and Professor in the Department of Chemistry and Biochemistry.

Klymenko and coworkers published a paper entitled “Heterogeneous cadherin expression and multicellular aggregate dynamics in ovarian cancer dissemination”.  The study work used a Field Emission Scanning Electron Microscope (FEI Magellen)  and a Transmission Electron Microscope (JEOL 1400) to evaluate the contribution of cellular cadherin composition to MCA phenotype by visualizing surface topography of 3-dimensional MCA’s grown in vitro using the panel of EOC cell lines, with high resolution and magnification ranges. Using these images, they were able to identify striking cadherin-dependent differences in aggregate surface ultrastructure.  Collectively, these findings support the hypothesis that MCA cadherin composition impacts intraperitoneal cell and MCA dynamics and thereby affects ultimate metastatic success.  The study was published in Neoplasia, 2017, 19 (7):549-63.